﻿                         SEQUENCE LISTING

<110>  惠觅宙
 
<120>  一种含有铝碳酸镁的药物组合物及制药用途

<130>  2017

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  1530
<212>  DNA
<213>  humane

<400>  1
gtcatcccag ctgaggagga gaacccggcc ttctggaacc gccaggcagc tgaggccctg     60

gatgctgcca agaagctgca gcccatccag aaggtcgcca agaacctcat cctcttcctg    120

ggcgatgggt tgggggtgcc cacggtgaca gccaccagga tcctaaaggg gcagaagaat    180

ggcaaactgg ggcctgagac gcccctggcc atggaccgct tcccatacct ggctctgtcc    240

aagacataca atgtggacag acaggtgcca gacagcgcag ccacagccac ggcctacctg    300

tgcggggtca aggccaactt ccagaccatc ggcttgagtg cagccgcccg ctttaaccag    360

tgcaacacga cacgcggcaa tgaggtcatc tccgtgatga accgggccaa gcaagcagga    420

aagtcagtag gagtggtgac caccacacgg gtgcagcacg cctcgccagc cggcacctac    480

gcacacacag tgaaccgcaa ctggtactca gatgctgaca tgcctgcctc agcccgccag    540

gaggggtgcc aggacatcgc cactcagctc atctccaaca tggacattga cgtgatcctt    600

ggcggaggcc gcaagtacat gtttcccatg gggaccccag accctgagta cccagctgat    660

gccagccaga atggaatcag gctggacggg aagaacctgg tgcaggaatg gctggcaaag    720

caccagggtg cctggtatgt gtggaaccgc actgagctca tgcaggcgtc cctggaccag    780

tctgtgaccc atctcatggg cctctttgag cccggagaca cgaaatatga gatccaccga    840

gaccccacac tggacccctc cctgatggag atgacagagg ctgccctgcg cctgctgagc    900

aggaaccccc gcggcttcta cctctttgtg gagggcggcc gcatcgacca tggtcatcat    960

gagggtgtgg cttaccaggc actcactgag gcggtcatgt tcgacgacgc cattgagagg   1020

gcgggccagc tcaccagcga ggaggacacg ctgaccctcg tcaccgctga ccactcccat   1080

gtcttctcct ttggtggcta caccttgcga gggagctcca tcttcgggtt ggcccccagc   1140

aaggctcagg acagcaaagc ctacacgtcc atcctgtacg gcaatggccc gggctacgtg   1200

ttcaactcag gcgtgcgacc agacgtgaat gagagcgaga gcgggagccc cgattaccag   1260

cagcaggcgg cggtgcccct gtcgtccgag acccacggag gcgaagacgt ggcggtgttt   1320

gcgcgcggcc cgcaggcgca cctggtgcat ggtgtgcagg agcagagctt cgtagcgcat   1380

gtcatggcct tcgctgcctg tctggagccc tacacggcct gcgacctggc gcctcccgcc   1440

tgcaccaccg acgccgcgca cccagttgcc gcgtcgctgc cactgctggc cgggaccctg   1500

ctgctgctgg gggcgtccgc tgctccctga                                    1530


<210>  2
<211>  1539
<212>  DNA
<213>  humane

<400>  2
atcatcccag ttgaggagga gaacccggac ttctggaacc gcgaggcagc cgaggccctg     60

ggtgccgcca agaagctgca gcctgcacag acagccgcca agaacctcat catcttcctg    120

ggcgatggga tgggggtgtc tacggtgaca gctgccagga tcctaaaagg gcagaagaag    180

gacaaactgg ggcctgagat acccctggcc atggaccgct tcccatatgt ggctctgtcc    240

aagacataca atgtagacaa acatgtgcca gacagtggag ccacagccac ggcctacctg    300

tgcggggtca agggcaactt ccagaccatt ggcttgagtg cagccgcccg ctttaaccag    360

tgcaacacga cacgcggcaa cgaggtcatc tccgtgatga atcgggccaa gaaagcaggg    420

aagtcagtgg gagtggtaac caccacacga gtgcagcacg cctcgccagc cggcacctac    480

gcccacacgg tgaaccgcaa ctggtactcg gacgccgacg tgcctgcctc cgcccgccag    540

gaggggtgcc aggacatcgc tacgcagctc atctccaaca tggacattga cgtgatccta    600

ggtggaggcc gaaagtacat gtttcgcatg ggaaccccag accctgagta cccagatgac    660

tacagccaag gtgggaccag gctggacggg aagaatctgg tgcaggaatg gctggcgaag    720

cgccagggtg cccggtatgt gtggaaccgc actgagctca tgcaggcttc cctggacccg    780

tctgtgaccc atctcatggg tctctttgag cctggagaca tgaaatacga gatccaccga    840

gactccacac tggacccctc cctgatggag atgacagagg ctgccctgcg cctgctgagc    900

aggaaccccc gcggcttctt cctcttcgtg gagggtggtc gcatcgacca tggtcatcat    960

gaaagcaggg cttaccgggc actgactgag acgatcatgt tcgacgacgc cattgagagg   1020

gcgggccagc tcaccagcga ggaggacacg ctgagcctcg tcactgccga ccactcccac   1080

gtcttctcct tcggaggcta ccccctgcga gggagctcca tcttcgggct ggcccctggc   1140

aaggcccggg acaggaaggc ctacacggtc ctcctatacg gaaacggtcc aggctatgtg   1200

ctcaaggacg gcgcccggcc ggatgttacc gagagcgaga gcgggagccc cgagtatcgg   1260

cagcagtcag cagtgcccct ggacgaagag acccacgcag gcgaggacgt ggcggtgttc   1320

gcgcgcggcc cgcaggcgca cctggttcac ggcgtgcagg agcagacctt catagcgcac   1380

gtcatggcct tcgccgcctg cctggagccc tacaccgcct gcgacctggc gccccccgcc   1440

ggcaccaccg acgccgcgca cccggggcgg tccgtggtcc ccgcgttgct tcctctgctg   1500

gccgggaccc tgctgctgct ggagacggcc actgctccc                          1539


<210>  3
<211>  1452
<212>  DNA
<213>  Artificial

<400>  3
gtcatcccag ctgaggagga gaacccggcc ttctggaacc gccaggcagc tgaggccctg     60

gatgctgcca agaagctgca gcccatccag aaggtcgcca agaacctcat cctcttcctg    120

ggcgatgggt tgggggtgcc cacggtgaca gccaccagga tcctaaaggg gcagaagaat    180

ggcaaactgg ggcctgagac gcccctggcc atggaccgct tcccatacct ggctctgtcc    240

aagacataca atgtggacag acaggtgcca gacagcgcag ccacagccac ggcctacctg    300

tgcggggtca aggccaactt ccagaccatc ggcttgagtg cagccgcccg ctttaaccag    360

tgcaacacga cacgcggcaa tgaggtcatc tccgtgatga accgggccaa gcaagcagga    420

aagtcagtag gagtggtgac caccacacgg gtgcagcacg cctcgccagc cggcacctac    480

gcacacacag tgaaccgcaa ctggtactca gatgctgaca tgcctgcctc agcccgccag    540

gaggggtgcc aggacatcgc cactcagctc atctccaaca tggacattga cgtgatcctt    600

ggcggaggcc gcaagtacat gtttcccatg gggaccccag accctgagta cccagctgat    660

gccagccaga atggaatcag gctggacggg aagaacctgg tgcaggaatg gctggcaaag    720

caccagggtg cctggtatgt gtggaaccgc actgagctca tgcaggcgtc cctggaccag    780

tctgtgaccc atctcatggg cctctttgag cccggagaca cgaaatatga gatccaccga    840

gaccccacac tggacccctc cctgatggag atgacagagg ctgccctgcg cctgctgagc    900

aggaaccccc gcggcttcta cctctttgtg gagggaggcc gcatcgacca tggtcatcat    960

gagggtgtgg cttaccaggc actcactgag gcggtcatgt tcgacgacgc cattgagagg   1020

gcgggccagc tcaccagcga ggaggacacg ctgaccctcg tcaccgctga ccactcccat   1080

gtgttctcct tcggcggcta ccccctgcgg ggctcctcca tcttcggcct ggcccccggc   1140

aaggcccggg accggaaggc ctacaccgtg ctgctgtacg gcaacggccc cggctacgtg   1200

ctgaaggacg gcgcccggcc cgacgtgacc gagtccgagt ccggctcccc cgagtaccgg   1260

cagcagtccg ccgtgcccct ggacgaggag acccacggcg gcgaggacgt ggccgtgttc   1320

gcccggggcc cccaggccca cctggtgcac ggcgtgcagg agcagtcctt cgtggcccac   1380

gtgatggcct tcgccgcctg cctggagccc tacaccgcct gcgacctggc cccccccgcc   1440

tgcaccaccg ac                                                       1452


<210>  4
<211>  509
<212>  PRT
<213>  humane

<400>  4

Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn Arg Gln Ala 
1               5                   10                  15      


Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile Gln Lys Val 
            20                  25                  30          


Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly Val Pro Thr 
        35                  40                  45              


Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly Lys Leu Gly 
    50                  55                  60                  


Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu Ala Leu Ser 
65                  70                  75                  80  


Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala Ala Thr Ala 
                85                  90                  95      


Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr Ile Gly Leu 
            100                 105                 110         


Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn Glu 
        115                 120                 125             


Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys Ser Val Gly 
    130                 135                 140                 


Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr Tyr 
145                 150                 155                 160 


Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Met Pro Ala 
                165                 170                 175     


Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile Ser 
            180                 185                 190         


Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met Phe 
        195                 200                 205             


Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala Ser Gln Asn 
    210                 215                 220                 


Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala Lys 
225                 230                 235                 240 


His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu Met Gln Ala 
                245                 250                 255     


Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe Glu Pro Gly 
            260                 265                 270         


Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp Pro Ser Leu 
        275                 280                 285             


Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro Arg 
    290                 295                 300                 


Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His His 
305                 310                 315                 320 


Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met Phe Asp Asp 
                325                 330                 335     


Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu Thr 
            340                 345                 350         


Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr Thr 
        355                 360                 365             


Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys Ala Gln Asp 
    370                 375                 380                 


Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro Gly Tyr Val 
385                 390                 395                 400 


Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu Ser Gly Ser 
                405                 410                 415     


Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser Glu Thr His 
            420                 425                 430         


Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His Leu 
        435                 440                 445             


Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val Met Ala Phe 
    450                 455                 460                 


Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro Ala 
465                 470                 475                 480 


Cys Thr Thr Asp Ala Ala His Pro Val Ala Ala Ser Leu Pro Leu Leu 
                485                 490                 495     


Ala Gly Thr Leu Leu Leu Leu Gly Ala Ser Ala Ala Pro 
            500                 505                 


<210>  5
<211>  484
<212>  PRT
<213>  humane

<400>  5

Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu Ala 
1               5                   10                  15      


Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr Ala 
            20                  25                  30          


Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser Thr 
        35                  40                  45              


Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu Gly 
    50                  55                  60                  


Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu Ser 
65                  70                  75                  80  


Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr Ala 
                85                  90                  95      


Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly Leu 
            100                 105                 110         


Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn Glu 
        115                 120                 125             


Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val Gly 
    130                 135                 140                 


Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr Tyr 
145                 150                 155                 160 


Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro Ala 
                165                 170                 175     


Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile Ser 
            180                 185                 190         


Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met Phe 
        195                 200                 205             


Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln Gly 
    210                 215                 220                 


Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala Lys 
225                 230                 235                 240 


Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln Ala 
                245                 250                 255     


Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro Gly 
            260                 265                 270         


Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser Leu 
        275                 280                 285             


Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro Arg 
    290                 295                 300                 


Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His His 
305                 310                 315                 320 


Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp Asp 
                325                 330                 335     


Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu Ser 
            340                 345                 350         


Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr Pro 
        355                 360                 365             


Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg Asp 
    370                 375                 380                 


Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr Val 
385                 390                 395                 400 


Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly Ser 
                405                 410                 415     


Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr His 
            420                 425                 430         


Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His Leu 
        435                 440                 445             


Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala Phe 
    450                 455                 460                 


Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro Ala 
465                 470                 475                 480 


Gly Thr Thr Asp 
                


<210>  6
<211>  484
<212>  PRT
<213>  Artificial

<400>  6

Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn Arg Gln Ala 
1               5                   10                  15      


Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile Gln Lys Val 
            20                  25                  30          


Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly Val Pro Thr 
        35                  40                  45              


Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly Lys Leu Gly 
    50                  55                  60                  


Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu Ala Leu Ser 
65                  70                  75                  80  


Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala Ala Thr Ala 
                85                  90                  95      


Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr Ile Gly Leu 
            100                 105                 110         


Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn Glu 
        115                 120                 125             


Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys Ser Val Gly 
    130                 135                 140                 


Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr Tyr 
145                 150                 155                 160 


Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Met Pro Ala 
                165                 170                 175     


Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile Ser 
            180                 185                 190         


Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met Phe 
        195                 200                 205             


Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala Ser Gln Asn 
    210                 215                 220                 


Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala Lys 
225                 230                 235                 240 


His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu Met Gln Ala 
                245                 250                 255     


Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe Glu Pro Gly 
            260                 265                 270         


Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp Pro Ser Leu 
        275                 280                 285             


Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro Arg 
    290                 295                 300                 


Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His His 
305                 310                 315                 320 


Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met Phe Asp Asp 
                325                 330                 335     


Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu Thr 
            340                 345                 350         


Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr Pro 
        355                 360                 365             


Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg Asp 
    370                 375                 380                 


Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr Val 
385                 390                 395                 400 


Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly Ser 
                405                 410                 415     


Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr His 
            420                 425                 430         


Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His Leu 
        435                 440                 445             


Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val Met Ala Phe 
    450                 455                 460                 


Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro Ala 
465                 470                 475                 480 


Cys Thr Thr Asp 
                


